Memory loss caused by Alzheimer’s can be restored

Research: It may be possible to restore memory function in Alzheimer's, preclinical study finds

Research: It may be possible to restore memory function in Alzheimer's, preclinical study finds

"Information from our study can help guide how we assess living Hispanic patients who may have Alzheimer's, to more accurately detect the disease in its early stages".

Neuroscience Research Australia (NeuRA), part of the Dominantly Inherited Alzheimer Network (DIAN), collaborated on a publication in Nature Medicine that details evidence for the blood test.

The authors of the new study published in Science Advances propose that Alzheimer's develops when gingipains accumulate fast enough to cause a patient to show symptoms.

To date, there is still not a 100 percent cure or remedy that stops or moderately slows down Alzheimer's and Dementia.

Singhrao, who has also conducted research into the cause of Alzheimer's, had earlier discovered that the bacteria invade the brains of mice which had gum infections.

University of Louisville researcher Jan Potempa, Ph.D., Department of Oral Immunology and Infectious Diseases in the School of Dentistry, was part of the team of worldwide scientists led by Cortexyme Inc., a privately held, clinical-stage pharmaceutical company.

Manager of Education and Outreach at the Alzheimers Association, Mayra Ligeza, spoke to the Downers Grove Library informing an audience of more than 30 people about the malignant disease. The most toxic enzymes were found in those with the worst cognitive decline - these samples also had more amyloid and tau protein accumulations.

In addition, the team identified toxic enzymes called gingipains secreted by the bacteria in the brains of Alzheimer's patients, which correlated with two separate markers of the disease: the tau protein, and a protein tag called ubiquitin.




Scientists analysed brain tissue, spinal fluid, and saliva from dead and living patients with diagnosed and suspected Alzheimer's.

Could these protein plaques be simply byproducts of the brain's defense mechanisms in the face of the real Alzheimer's causing germ? Giving some of these to mice reduced their infections, halted amyloid production, lowered brain inflammation and even rescued damaged neurons. "We will have to see the outcome of this ongoing trial before we know more about its potential as a treatment for Alzheimer's", he said.

Now, a team led by University of Buffalo scientists has revealed a new and hopeful approach to Alzheimer's that may even eventually make it possible to reverse memory loss. The protein demonstrates how much nerve cell loss you have in your brain - if you have more NfL in your blood, that means you have more brain damage.

David Reynolds, chief scientific officer at Alzheimer's Research UK, says that the idea of gum disease having a link to Alzheimer's disease has been circulating for a number of years, but that this work is "a step forward".

He says it is important to remember that the study was carried out by a company developing gingipain antagonists to treat dementia. COR388 showed positive trends across several cognitive tests in patients suffering from AD, and Cortexyme plans to initiate a Phase 2 and 3 clinical trial of COR388 in mild to moderate AD in 2019.

Infecting tau-expressing cell cultures with P. gingivalis led to breakdown of the tau protein, apparently through the actions of those gingipain proteases.

Authors say the data suggests it may be more hard for clinicians to detect AD in its mild to moderate stages among living Hispanic patients compared to non-Hispanic patients.

In 2014, using a blood test that looked at 10 specific lipids in people's blood, researchers were also able to predict Alzheimer's before symptoms appeared.

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